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Support the Transplant Surgery Program in the quest to discover new treatments for diseases of the kidney, liver and pancreas and to improve transplantation outcomes.
Ryutaro Hirose, M.D.
Professor of Clinical Surgery
Division of Transplant Surgery
Associate Program Director,
UCSF General Surgery Residency Program
Contact Information
(415) 353-1551 Clinical, Kidney and Pancreas
(415) 353-8783 Academic
Ryutaro.Hirose@ucsfmedctr.org
BiographyEducation
- Columbia College, Columbia University, B.A., Mathematics, 1981-85
- Columbia University College of Physicians And Surgeons, M.D., 1985-89
Residencies
- University of California, San Francisco, Intern and Resident, Surgery, 1989-92
- University of California, San Francisco, Resident, Surgery, 1995-96
- University of California, San Francisco, Chief Resident, Surgery, 1996-97
Fellowships
- University of California, San Francisco, Fellow, Transplant Surgery, 1997-99
Postdoctoral Training
- University of California, San Francisco, Postdoctoral Fellow, Molecular Medicine, 1992-95
Board Certification
- American Board of Surgery, 1998
Clinical Expertise
- Bile Duct Cancer (Cholangiocarcinoma)
- Bile Duct Injuries
- Bile Duct Strictures
- Complex Cancer Resections
- Fulminant Hepatic Failure
- Hepatitis B
- Hepatitis C
- Hepatocellular Carcinoma (Liver Cancer)
- Kidney Transplantation
- Liver Resection
- Liver Transplantation
- Living Donor Kidney Transplantation
- Living Donor Liver Transplantation
- Pancreas Transplants
- Pediatric Kidney Transplantation
- Pediatric Liver Transplantation
- Portal Hypertension
- Radio Frequency Ablation (RFA)
- Surgical Shunts
Research Interests
- Ischemia Reperfusion Injury in Fatty Livers
- Ischemia-reperfusion Injury in Kidneys and Hyperglycemia
- Living Donor Liver Transplantation
- Non-melanoma Skin Cancer in Organ Transplant Patients
- Outcomes in Renal Transplant Recipients
- Pathogenesis of Focal Segmental Glomerulosclerosis
Biography
Ryutaro Hirose is a Professor of Clinical Surgery at UCSF and performs liver, kidney and pancreas transplants. After graduating from Columbia College of Physicians and Surgeons, he completed his clinical and research training at UCSF as a resident in general surgery as well as a fellow in molecular medicine and transplantation surgery. His research interests include renal and hepatic ischemia - reperfusion injury, immune monitoring and skin cancer in transplant recipients. He has received funding from the NIH, NKF, UCSF, ASTS, and private industry. He is also actively involved with teaching students and residents. Dr. Hirose is currently the Associate Program Director for the General Surgery Residency at UCSF.
Research Summary
Dr. Hirose's research focus is ischemia-reperfusion injury and potential interventions to ameliorate renal and hepatic I-R injury. His group uses animal models, performs clinical and translational research as well as research on deceased donors. He collaborates with Dr. Claus Niemann, MD from the Dept. Anesthesia and they are co-Directors of the Ischemic Organ Injury Lab.
Selected Publications
- Validity of patient skin cancer report among organ transplant recipients.Dybbro E, Mihalis E, Hirose R, Arron ST. Clin Transplant. 2012 Mar 20
- Can we cure cholangiocarcinoma with neoadjuvant chemoradiation and liver transplantation? Time for a multicenter trial. Kelley RK, Hirose R, Venook AP. Liver Transpl. 2012 Mar 5.
- Intraoperative hyperglycemia augments ischemia reperfusion injury in renal transplantation: a prospective study. Parekh J, Niemann CU, Dang K, Hirose R.J Transplant. 2011;2011:652458
- Donor pre-treatment with everolimus or cyclosporine does not reduce ischaemia-reperfusion injury in a rat kidney transplant model. Martinez-Palli G, Hirose R, Liu T, Xu F, Dang K, Feiner J, Serkova NJ, Niemann CU. Nephrol Dial Transplant. 2011 Jun;26(6):1813-20
- Hepatic surgery at a VA tertiary medical center: lessons learned. Alemi F, Kwon E, Freise C, Kang SM, Hirose R, Stewart L, Corvera CU. Am J Surg. 2010 Nov;200(5):591-5
- Induction of intestinal ischemia reperfusion injury by portal vein outflow occlusion in rats.Vincenti M, Behrends M, Dang K, Park YH, Hirose R, Blasi-Ibanez A, Liu T, Serkova NJ, Niemann CU. J Gastroenterol. 2010 Nov;45(11):1103-10
In the News
Teen Liver Transplant Recipient to Honor Donor at 2013 Rose Parade
UCSF News - Dec 28, 2012
Three years
ago, Alfonso Garcia was diagnosed with Wilson's disease and was in
desperate need of a liver transplant. George Becker, who signed up
to be an organ donor on his driver's license when he was 16, ended
up being the right match. Garcia's UCSF medical team - which
included transplant surgeon Ryutaro Hirose, MD (pictured
first); Philip Rosenthal, MD (pictured
second), medical director of the Pediatric Liver Transplant
Program;
Emily Perito, MD, a clinical fellow in pediatrics and
gastroenterology; and nurse practitioner Susan Diaz, MSN -
performed a successful transplant.Since receiving the liver
transplant, Garcia has made it a mission to spread the word about
the value of organ donation by sharing the memory of his hero,
George Becker, who died after a bad sinus infection spread to his
brain. As part of that mission, Garcia was selected by UCSF and the
California Transplant Donor Network to ride on the Donate Life
"Journeys of the Heart" float at the 2013 Tournament of Roses
Parade in Pasadena, Calif., on Tuesday, Jan. 1., in honor of
Becker. The float will bear a florograph of Becker - a portrait
made of flowers.UCSF Patients Part of Nation's Longest Living Kidney Transplant Chain
UCSF News - Mar 15, 2012"Neither man had a donor who was a match. But each had a family member willing to donate a kidney to a stranger, allowing them all to be part of chain which would, in turn, give Baty and Cienfuegos kidneys from other strangers. With 17 participating hospitals in 11 states, the chain consisted of 30 people willing to give up their kidney, matched with 30 more who needed one to survive. UCSF surgeons Andrew Posselt, M.D., Ph.D. and Ryutaro Hirose, M.D., performed the transplants on Baty and Cienfuegos - just two of the 300 or so kidney transplants performed at UCSF every year."
UCSF Receives Grant to Improve Outcomes in Organ Donor Transplantation
UCSF News - Oct 20, 2011Claus Niemann, MD, Associate Professor in the UCSF Department of Anesthesia and Perioperative Care and co-Director of the Ischemic Organ Injury Lab (pictured left), has been awarded a $2 million grant by the Health Resources and Services Administration (HRSA) to improve outcomes in organ donor transplantation. The grant award also included collaborators John Feiner, MD, Ryutaro Hirose, MD, and John Roberts, MD, chief of the UCSF Division of Transplant Surgery, the California Transplant Donor Network and Darren Malinoski, MD, of Cedars-Sinai Medical Center in Los Angeles. The innovative project is designed to determine the optimal management of organ donors before the procurement operation occurs. Research in this area has been hindered by numerous obstacles including the logistical challenges of conducting research in large hospitals in California and northern Nevada.
Teen Liver Transplant Recipient Throws Opening Pitch
Division of Transplant Surgery - Aug 22, 2011"Alfonso Garcia, the son of a respiratory therapist at UCSF Medical Center, was a typical, healthy 15-year-old when he started feeling sick ─ feverish, anemic, fatigued and jaundiced. Alfonso learned he had Wilson's disease, a rare genetic disorder in which copper isn't properly eliminated from the body and damages the liver and nervous system. He and his family received a grave prognosis. He had just 48 hours to find a liver transplant or he might not survive. With the help of Philip Rosenthal, M.D., (left) a pediatric liver specialist, and Ryutaro Hirose, M.D. (right), an organ transplant surgeon, Alfonso received a successful, emergency liver transplant. The donor was another young man, a 22-year-old from Sacramento who had lost his life suddenly due to a sinus infection that had spread to his brain."
UCSF Liver Transplant Team Shares Expertise in Latin America
UCSF News Office - Mar 23, 2011"Previously, Uruguay had tried to go it alone, but high mortality rates soon caused doctors to shut the program down. After their initial visit, the UCSF transplant team, including anesthesiologist Claus Niemann, MD (pictured first), and surgeons Ryutaro Hirose, MD (pictured second), and Peter Stock, MD, PhD, (pictured third) continued to consult with the team in Uruguay, guiding them through everything from patient selection procedures to the use of immunosuppressive medications following surgery. When it came time for Uruguayan doctors to conduct their first liver transplant since revamping the program, UCSF doctors oversaw the operation by dialing in via Skype."
The Domino Effect - Woman gets new liver, gives her old one to save another life
San Francisco Chronicle, CA - Aug 22, 2000"The next day, surgeons at the University of California at San Francisco performed a rare liver transplant called a ``domino transplant,'' the first in the Bay Area and one of just a handful done in the United States. ........................Her choice was to have a liver that will give her a disease in 30 years, or die of cancer in the next year,'' said Dr. Ryutaro Hirose (pictured left), the surgeon for both transplants. ``She jumped at the chance, and most people would.''
