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James M. Gardner, M.D., Ph.D.

James M. Gardner, M.D., Ph.D.

Abdominal Transplant Fellow (PGY-6)
Division of Transplant Surgery

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  • Harvard University, B.A., Biochemical Sciences, 2002
  • University of California San Francisco, M.D., Ph.D. 2012
  • University of California San Francisco, Intern, General Surgery. 2012-2013
  • University of California San Francisco, Resident, General Surgery. 2013-2016
  • University of California San Francisco, Chief Resident, General Surgery, 2016-2017
  • UCSF Department of Surgery
  • UCSF Division of Transplant Surgery
  • UCSF Diabetes Center
  • Transplant Surgery
  • General Surgery
  • Immune tolerance
  • Autoimmmune diabetes
  • Transplant surgery
James M. Gardner, M.D., Ph.D. is a General Surgery chief resident in the Department of Surgery and a research fellow in the UCSF Diabetes Center. Dr. Gardner obtained a B.A. from Harvard University in Biochemical Sciences and his M.D. and Ph.D. degrees from UCSF. He is continuing his training as the 2017 fellow in Abdominal Transplant Surgery at UCSF.
Dr. Gardner's research is focused on the mechanisms regulating self-tolerance in the adaptive immune system, and translating these findings into relevant therapeutics for inducing and maintaining donor-specific tolerance. In mentored collaboration with the Mark Anderson lab at the UCSF Diabetes Center, Dr. Gardner's studies focus on a gene called the Autoimmune Regulator, or Aire, which is a key regulator of central tolerance. Dr. Gardner and Dr. Anderson have defined a novel population of extrathymic Aire-expressing cells (eTACs), and their work focuses on the role of this population in autoimmunity and tolerance.
  • American Society of Transplant Surgeons Fellowship in Transplantation Grant 2017
  • NIH/NIHAI R01 - Developing eTACs as a Novel Method of Tolerance in Type 1 Diabetes
  • American Diabetes Association Young Investigator Award
  1. Wisel SA, Gardner JM, Roll GR, Harbell J, Freise CE, Feng S, Kang SM, Hirose R, Kaufman DB, Posselt AM, Stock PG. Pancreas-After-Islet Transplantation in Nonuremic Type 1 Diabetes: A Strategy for Restoring Durable Insulin Independence. Am J Transplant. 2017 Sep; 17(9):2444-2450. View in PubMed
  2. Cho DY, Sinha SR, Gardner JM, Schaller MP, Pamnani RD, Felt SA, Barral JK, Messner AH. Effect of intratonsillar injection of steroids on the palatine tonsils of rabbits. Laryngoscope. 2014 Dec; 124(12):2811-7. View in PubMed
  3. Metzger TC, Khan IS, Gardner JM, Mouchess ML, Johannes KP, Krawisz AK, Skrzypczynska KM, Anderson MS. Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell population. Cell Rep. 2013 Oct 17; 5(1):166-79. View in PubMed
  4. Gardner JM, Metzger TC, McMahon EJ, Au-Yeung BB, Krawisz AK, Lu W, Price JD, Johannes KP, Satpathy AT, Murphy KM, Tarbell KV, Weiss A, Anderson MS. Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4? T cells. Immunity. 2013 Sep 19; 39(3):560-72. View in PubMed
  5. Yadav M, Louvet C, Davini D, Gardner JM, Martinez-Llordella M, Bailey-Bucktrout S, Anthony BA, Sverdrup FM, Head R, Kuster DJ, Ruminski P, Weiss D, Von Schack D, Bluestone JA. Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo. J Exp Med. 2012 Sep 24; 209(10):1713-22, S1-19. View in PubMed
  6. Gardner JM, Anderson MA. Immunoendocrinology: Scientific and Clinical Aspects. Eisenbarth, GS (Ed.). The Mouse Model of Autoimmune Polyglandular Syndrome Type I. 2011; 1(1):95-113. View in PubMed
  7. Gardner JM, Fletcher AL, Anderson MS, Turley SJ. AIRE in the thymus and beyond. Curr Opin Immunol. 2009 Dec; 21(6):582-9. View in PubMed
  8. Gardner JM, Anderson MS. The sickness unto Deaf. Nat Immunol. 2009 Sep; 10(9):934-6. View in PubMed
  9. Gardner JM, Devoss JJ, Friedman RS, Wong DJ, Tan YX, Zhou X, Johannes KP, Su MA, Chang HY, Krummel MF, Anderson MS. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science. 2008 Aug 08; 321(5890):843-7. View in PubMed
  10. Lewinsohn DA, Heinzel AS, Gardner JM, Zhu L, Alderson MR, Lewinsohn DM. Mycobacterium tuberculosis-specific CD8+ T cells preferentially recognize heavily infected cells. Am J Respir Crit Care Med. 2003 Dec 01; 168(11):1346-52. View in PubMed
Publications provided by UCSF Profiles, powered by CTSI at UCSF. View profile of James M. Gardner, M.D., Ph.D.
Please note: UCSF Profiles publications are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact CTSI for help.
  1. Gardner et al., American Transplant Congress, 2015. Outcomes in a new category of Pancreas-After-Islet Transplantation.
  2. Gardner et al., UCSF Surgery Resident Research Symposium, 2013-2016. Extrathymic Aire-Expressing Cells in Immune Tolerance and Transplantation.
  3. Gardner et al., International Pancreas and Islet Transplant Association 2013. Outcomes in a new category of Pancreas-After-Islet Transplantation.
  4. Gardner et al., Children?s Diabetes Foundation of the North Bay Annual Retreat, 2010. Novel Approaches for Preventing and Treating Juvenile Diabetes: What?s on the Horizon?
  5. Gardner et al., Kyoto T Cell Conference 2009. Extrathymic Aire-Expressing Cells and the Maintenance of Immunologic Tolerance.
  6. Gardner et al., American Diabetes Association Tour de Cure Donors? Evening, 2008. New approaches to Preventing and Treating Autoimmune Diabetes.
  7. Gardner et al., UCSF/UCB 2008 Immunology Retreat. Phenotypic and Functional Characterization of Extrathymic Aire-Expressing Cells.
  1. Gardner JM, Anderson MS. The Mouse Model of Autoimmune Polyglandular Syndrome Type I. Immunoendocrinology: Scientific and Clinical Aspects. 1st edition. Ed. Eisenbarth G. (New York: Humana Press, 2011.)

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