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Claus U. Niemann, M.D.

Claus U. Niemann, M.D.

  • Professor of Anesthesia and Surgery
  • Department of Anesthesia & Perioperative Care
  • Department of Surgery
  • Co-Director, Ischemic Organ Injury Lab

Contact Information

University of California, San Francisco
500 Parnassus MUE 4th Floor
Box 0648
San Francisco, Ca 94143-0648
Tel: 415-502-2162
[email protected]
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  • 1986-93, Ludwig-Maximilians University, Munich, Germany, M.D.
  • 1993-94  Intern ;  City Hospital St. Georg,, University of Hamburg, Germany and Klinikum Grosshadern, Ludwig-Maximilians University, Munich, Germany
  • 1996-99, University of California, San Francisco, Resident, Anesthesia
  • 1999-01, University of California, San Francisco, Fellow, Liver Transplant Research
  • 1994-96, Department of Anesthesiology, Northwestern University, Chicago, Illinois, Fellow, Postdoctoral Research
  • American Board of Anesthesiology
  • Department of Anesthesia and Perioperative Care
  • Department of Surgery, Division of Transplantation
  • UCSF Liver Center
  • Kidney Transplantation
  • Liver Transplantation
  • Pancreas Transplantation
  • View Research Profile at UCSF Clinical & Translational Science Institute

  • Inflammatory response to injuryIschemia reperfusion injury
  • Intensive Insulin Therapy in Deceased Donors-to improve renal allograft function and transplanted allograft outcomes
  • Liver transplantation
  • Metabolomics
  • Organ donation
  • Renal and hepatic injury during surgery
My group is interested in identifying why obese individuals are at greater risk of liver injury in the setting of trauma or surgery. My long-term goal is to understand the relationship between metabolic and immunologic processes in the liver. One potential link between these underlying mechanisms could be the peptide leptin, which can profoundly modify inflammatory and metabolic pathways. The goal of this research effort is to improve understanding of the impact of leptin on acute inflammatory cascade and metabolic response during hepatic ischemia-reperfusion. This will benefit patients by improving risk-stratification of candidates for hepatic surgery and possibly lead to preventive therapies for ischemia-reperfusion injury.

My group is interested in identifying why obese individuals are at greater risk of liver injury in the setting of trauma or surgery. My long-term goal is to understand the relationship between metabolic and immunologic processes in the liver. One potential link between these underlying mechanisms could be the peptide leptin, which can profoundly modify inflammatory and metabolic pathways. The goal of this research effort is to improve understanding of the impact of leptin on acute inflammatory cascade and metabolic response during hepatic ischemia-reperfusion. This will benefit patients by improving risk-stratification of candidates for hepatic surgery and possibly lead to preventive therapies for ischemia-reperfusion injury. 

Data provided by UCSF Profiles, powered by CTSI
MOST RECENT PUBLICATIONS FROM A TOTAL OF 121
Data provided by UCSF Profiles, powered by CTSI
  1. Rodriguez-Davalos MI, Lopez-Verdugo F, Kasahara M, Muiesan P, Reddy MS, Flores-Huidobro Martinez A, Xia Q, Hong JC, Niemann CU, Seda-Neto J, Miloh TA, Yi NJ, Mazariegos GV, Ng VL, Esquivel CO, Lerut J, Rela M, Pediatric Liver Transplantation Global Census Group. International Liver Transplantation Society Global Census: First Look at Pediatric Liver Transplantation Activity Around the World. Transplantation. 2023 10 01; 107(10):2087-2097. View in PubMed
  2. Galli AM, Kothari R, Adelmann D, Holm Z, Bokoch MP, De Gasperi A, Niemann CU, Kolodzie K. Lactate concentration at the end of liver transplant: Early predictor of graft function or just one piece of the puzzle? Clin Transplant. 2023 10; 37(10):e15057. View in PubMed
  3. Rodriguez-Davalos MI, Lopez-Verdugo F, Kasahara M, Muiesan P, Reddy MS, Flores-Huidobro Martinez A, Xia Q, Hong JC, Niemann CU, Seda-Neto J, Miloh TA, Yi NJ, Mazariegos GV, Ng VL, Esquivel CO, Lerut J, Rela M, Pediatric Liver Transplantation Global Census Group. International Liver Transplantation Society Global Census: First Look at Pediatric Liver Transplantation Activity Around the World. Transplantation. 2023 Jun 08. View in PubMed
  4. Malinoski D, Saunders C, Swain S, Groat T, Wood PR, Reese J, Nelson R, Prinz J, Kishish K, Van De Walker C, Geraghty PJ, Broglio K, Niemann CU. Hypothermia or Machine Perfusion in Kidney Donors. N Engl J Med. 2023 02 02; 388(5):418-426. View in PubMed
  5. Pollok JM, Tinguely P, Berenguer M, Niemann CU, Raptis DA, Spiro M, ERAS4OLT.org collaborative. Enhanced recovery for liver transplantation: recommendations from the 2022 International Liver Transplantation Society consensus conference. Lancet Gastroenterol Hepatol. 2023 01; 8(1):81-94. View in PubMed
  6. View All Publications

 

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