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Paul R. Brakeman, M.D., Ph.D.

Paul R. Brakeman, M.D., Ph.D.

Associate Clinical Professor of Pediatrics
Medical Director, Pediatric Dialysis Unit
Division of Pediatric Nephrology
Department of Pediatrics

Contact Information

Academic
Room U585, Box 0748
San Francisco, CA 94143-0748 
Phone: 415-476 2423
Fax: 415-476 9976
Email: brakemanp@peds.ucsf.edu

Clinic/Appointments

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  • University of California, Berkeley, B.A., Biophysics, 1985-1989
  • Johns Hopkins University School of Medicine, M.D., 1989-1997
  • Johns Hopkins University School of Medicine, Ph.D., Neuroscience, 1989-1997
  • University of California, San Francisco, Resident, Pediatrics, 1997-2000
  • University of California, San Francisco, Chief Resident, Pediatrics, 2000-2001
  • University of California, San Francisco, Fellowship, Pediatric Nephrology, 2001-2004
  • American Board of Pediatrics - General Pediatrics
  • American Board of Pediatrics - Pediatric Nephrology Subspecialty
  • Chronic kidney disease
  • Obstructive nephropathy
  • Pediatric dialysis
  • Systemic lupus erythematous
  • Urinary tract infection
  • Artificial kidney engineering
  • Kidney development
  • Sodium and water transport

Dr. Brakeman is an Associate Professor based at the UCSF Benioff Children's Hospital with a primary appointment in Pediatrics and a secondary appointment in the Division of Nephrology in the Department of Medicine. He completed his undergraduate training at UC Berkeley in biophysics before entering a combined MD/PhD program at the Johns Hopkins University School of Medicine. His thesis work consisted of evaluating the role of immediate early genes in learning and memory during brain development. He completed his MD and PhD degrees in 1997 before coming to UCSF to pursue residency in the Department of Pediatrics. Dr. Brakeman served as chief resident in pediatrics in 2000-2001 and then went on to become a fellow in the Division of Pediatric Nephrology at UCSF. During his fellowship, Dr. Brakeman began his renal research career, studying kidney development and the molecular mechanisms of kidney morphogenesis. Dr. Brakeman joined the UCSF faculty after completing his fellowship in 2004.

Since joining the UCSF faculty, Dr. Brakeman has developed clinical expertise in the evaluation and treatment of pediatric dialysis patients, pediatric chronic kidney disease, urinary tract infections and obstructive nephropathy. 

  • Basil O'Connor Award, March of Dimes, 2010-2012
  • Travel Award, 10th International Developmental Nephrology Workshop, 2007
  • Fellow, Pediatric Scientist Development Program, 2002-2004

The primary focus of Dr. Brakeman's research is the engineering of human renal epithelial cells for use in a bioartificial kidney. Work is currently underway at UCSF on a multi-center project to develop a bioartificial implantable renal assist device based on hemofiltration. One of the important components of an implantable bioartificial device is an active renal proximal tubule cell bioreactor that can provide some of the metabolic activity of renal tubules. Another critical function of the cellular bioreactor will be the reabsorption of salt and water in order to reduce the volume of the filtrate generated as much as possible before elimination via the bladder. Dr. Brakeman's lab is focused on engineering human proximal tubules cells to enhance sodium and water reabsorption for use in the bioartificial kidney. In addition, he is actively evaluating the use of the proximal tubule cell bioreactor for use in toxicology and pharmaceutical evaluation of novel compounds. 

Dr. Brakeman's work is funded by the Roger's Family Foundation.

Most recent publications from a total of 27
  1. Onder AM, Flynn JT, Billings AA, Deng F, DeFreitas M, Katsoufis C, Grinsell MM, Patterson LT, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chadha V, Elmaghrabi A, Lin JJ, Butani L, Haddad M, Couloures OM, Brakeman P, Quigley R, Shin HS, Garro R, Liu H, Rahimikollu J, Raina R, Langman CB, Wood EG. Correction to: Predictors of patency for arteriovenous fistulae and grafts in pediatric hemodialysis patients. Pediatr Nephrol. 2019 Jan 25. View in PubMed
  2. Zinter MS, Spicer AC, Liu KD, Orwoll BE, Alkhouli MF, Brakeman PR, Calfee CS, Matthay MA, Sapru A. Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury. Pediatr Crit Care Med. 2019 Jan 21. View in PubMed
  3. Onder AM, Flynn JT, Billings AA, Deng F, DeFreitas M, Katsoufis C, Grinsell MM, Patterson LT, Jetton J, Fathallah-Shaykh S, Ranch D, Aviles D, Copelovitch L, Ellis E, Chanda V, Elmaghrabi A, Lin JJ, Butani L, Haddad M, Couloures OM, Brakeman P, Quigley R, Stella Shin H, Garro R, Liu H, Rahimikollu J, Raina R, Langman CB, Wood EG. Predictors of patency for arteriovenous fistulae and grafts in pediatric hemodialysis patients. Pediatr Nephrol. 2019 Feb; 34(2):329-339. View in PubMed
  4. Gomez Mendez LM, Cascino MD, Garg J, Katsumoto TR, Brakeman P, Dall'Era M, Looney RJ, Rovin B, Dragone L, Brunetta P. Peripheral Blood B Cell Depletion after Rituximab and Complete Response in Lupus Nephritis. Clin J Am Soc Nephrol. 2018 Oct 08; 13(10):1502-1509. View in PubMed
  5. Wang MK, Chuang KW, Li Y, Gaither T, Brakeman P, Gonzalez L, Brennan J, Baskin LS. Renal function outcomes in pediatric patients with symptomatic reflux into the transplanted kidney treated with redo ureteroneocystostomy. J Pediatr Urol. 2018 Jun; 14(3):275.e1-275.e5. View in PubMed
  6. Gao L, Yang Z, Hiremath C, Zimmerman SE, Long B, Brakeman PR, Mostov KE, Bryant DM, Luby-Phelps K, Marciano DK. Afadin orients cell division to position the tubule lumen in developing renal tubules. Development. 2017 10 01; 144(19):3511-3520. View in PubMed
  7. Oates A, Benedict KA, Sun K, Brakeman PR, Lim J, Kim C. Laser acupuncture reduces pain in pediatric kidney biopsies: a randomized controlled trial. Pain. 2017 01; 158(1):103-109. View in PubMed
  8. Brakeman P, Miao S, Cheng J, Lee CZ, Roy S, Fissell WH, Ferrell N. A modular microfluidic bioreactor with improved throughput for evaluation of polarized renal epithelial cells. Biomicrofluidics. 2016 Nov; 10(6):064106. View in PubMed
  9. Kim S, Heller J, Iqbal Z, Kant R, Kim EJ, Durack J, Saeed M, Do L, Hetts S, Wilson M, Brakeman P, Fissell WH, Roy S. Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy. ASAIO J. 2016 Mar-Apr; 62(2):169-75. View in PubMed
  10. Tran CS, Eran Y, Ruch TR, Bryant DM, Datta A, Brakeman P, Kierbel A, Wittmann T, Metzger RJ, Mostov KE, Engel JN. Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection. Cell Host Microbe. 2014 May 14; 15(5):636-43. View in PubMed
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